
Multiple sclerosis (MS) is an unpredictable disorder that can cause a variety of symptoms, which for many, can flare-up and then subside over the course of days, months, or even years. Most individuals are initially diagnosed with one of the relapsing forms of MS, causing these flare-ups. A much smaller percentage of individuals begin with one of the progressive forms, exhibiting a more steady progression of symptoms.

The first three long-term treatments for multiple sclerosis (MS) became available in the early to mid 1990s and were dubbed the “A-B-C” drugs because of their brand names: Avonex®, Betaseron®, and Copaxone®. These are interferon beta-1a, interferon beta-1b, and glatiramer acetate, respectively. In 2002, the United States Food and Drug Administration (FDA) approved another interferon, Rebif® (interferon beta-1a), for the long-term treatments of MS.

Relapses, also referred to as exacerbations, attacks, flare-ups, episodes, or bouts, are initially experienced by most people diagnosed with multiple sclerosis (MS). Relapses occur with relapsing-remitting and sometimes secondary-progressive forms of MS. Relapses do not occur with primary-progressive MS, although individuals may experience day-to-day fluctuations in how they feel.

MS may cause several different symptoms. The specific symptoms, as well as the number and severity of symptoms, differ greatly between people with MS. When experiencing one or more new symptoms, or a worsening of an existing symptom, individuals should always consult their physician.For more information on symptom, MSAA offers publications, webinars, videos, and podcasts.